Azure OpenAI, a cutting-edge service by Microsoft, harnesses the power of OpenAI's Large Language Model (LLM) to drive cloud-based innovations within enterprises. This service integrates advanced LLM models into business functions, transforming Microsoft products like GitHub Copilot, Microsoft 365 Copilot, and Bing Chat, making them more advanced and interactive. Azure OpenAI is accessible via REST APIs, Python SDK, or Azure OpenAI Studio, opening doors to build innovative AI applications. This book is a comprehensive guide to build GenAI applications using Azure OpenAI. It begins with the fundamentals, including how to access Azure OpenAI and how to effectively utilize its REST API and Python SDK. It takes a deep dive into various AI models and emphasizes the crucial aspects of prompt engineering and fine-tuning for optimal output. It further underlines the significance of content filters and prevention of misuse, maintaining a strong focus on safety and security protocols and finally the significance of Azure OpenAI Studio in deployment and administration is emphasized. Practical applications are showcased like content generations, summarization, semantic search, code documentation and code generation. Combining Azure Cognitive services amplifies Generative AI potential and finally aligns with Microsoft's ethical AI principles.