Discovering the function of a protein sequence is a key task. We can do this in many ways, including by conducting whole sequence similarity searches against databases of known proteins using tools such as BLAST. If we want more informative and granular information, we can instead look for individual functional domains within a sequence. Databases such as Pfam and tools such as hmmer make this possible. Pfam encodes protein domains as profile Hidden Markov Models, which hmmer uses to scan sequences and report any likely occurrences of the domains. Often, genome annotation projects will carry out the searches for us, meaning that finding the Pfam domains in our sequence is a question of searching a database. Bioconductor does a great job of packaging up the data in these databases in particular packages—usually suffixed with .db...
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R Bioinformatics Cookbook
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R Bioinformatics Cookbook
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Overview of this book
Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples.
This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse.
By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data.
Table of Contents (13 chapters)
Preface
Free Chapter
Performing Quantitative RNAseq
Finding Genetic Variants with HTS Data
Searching Genes and Proteins for Domains and Motifs
Phylogenetic Analysis and Visualization
Metagenomics
Proteomics from Spectrum to Annotation
Producing Publication and Web-Ready Visualizations
Working with Databases and Remote Data Sources
Useful Statistical and Machine Learning Methods
Programming with Tidyverse and Bioconductor
Building Objects and Packages for Code Reuse
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